.beta.-Lactam antibiotics their preparation and their use

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424274, 424269, 424270, 424273R, 424114, 544 36, C07D48704

Patent

active

044380364

ABSTRACT:
The present invention provides a process for inversion of the absolute stereochemistry at the .alpha.-carbon atom of a C-6 substituent of a bicyclic carbapenem antibiotic via a phosphorus - azodicarboxylate mediated reaction. Novel azides, amines and formates are described as useful intermediates and as antibacterial agents.

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