Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1982-07-29
1984-09-25
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
2602452T, 2602452R, A61K 31395, C07D48704
Patent
active
044735782
ABSTRACT:
The compounds of the formula: ##STR1## and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof wherein R.sup.1 is a hydrogen atom or a group selected from OH, OSO.sub.3 H or a pharmaceutically acceptable salt or C.sub.1-4 alkyl ester thereof, OR.sup.2, SR.sup.3, OCOR.sup.2, OCO.sub.2 R.sup.3 or OCONHR.sup.3, where R.sup.2 is a C.sub.1-6 alkyl group or an optionally substituted benzyl group and R.sup.3 is a C.sub.1-6 alkyl group or an optionally substituted benzyl or an optionally substituted phenyl group; and R.sup.22 is a hydrogen atom, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 alkynyl wherein the triple bond is not present on the carbon adjacent to the sulphur atom, aralkyl, C.sub.1-6 alkanoyl, aralkanoyl, aryloxyalkanoyl or arylcarbonyl, any of such R.sup.22 groups being optionally substituted; with the proviso that when R.sup.22 is 2-aminoethyl R.sup.1 must be SR.sup.3 or OSO.sub.3 H or a pharmaceutically acceptable salt of C.sub.1-4 alkyl ester thereof; have been found to be antibacterially active. Their use is described as are processes for their preparation.
REFERENCES:
patent: 4203902 (1980-05-01), Shih
patent: 4347367 (1982-08-01), Christensen et al.
patent: 4347368 (1982-08-01), Christensen et al.
Beecham Group Limited
Rizzo Nicholas S.
LandOfFree
.beta.-Lactam antibiotics and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .beta.-Lactam antibiotics and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .beta.-Lactam antibiotics and their use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1769551