.beta.Lactam antibiotics and process for their use

Details .beta.Lactam antibiotics and process for their use .beta.Lactam antibiotics and process for their use

1975-11-13

1979-04-03

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424271, 542420, 2602391, 544 17, A61K 3154, A61K 31545, C07D50134, C07D49946

Patent

active

041476930

ABSTRACT:
6-[.alpha.-(Imidazolidin-2-on-1-ylcarbonylamino)-substutited acetamido]penicillanic acids, and the correspondingly 7-substituted ceph-3-em-4-carboxylic acids, characterized by the presence of a methyleneamino or substituted methyleneamino group on the 3-nitrogen atom of the imidazolidine ring are antibacterial agents. The compounds, of which 6-[.alpha.-(3-benzaliminoimidazolidin-2-on-1-ylcarbonylamino)cyclohe xa-1,4-dien-1-ylacetamido]penicillanic acid and 7-[.alpha.-(3-furylideneaminoimidazolidin-2-on-1-ylcarbonylamino)phenylace tamido]-3-(3-methylthiadiazol-5-ylthiomethyl)ceph-3-em-4-carboxylic acid are typical examples, are prepared through acylation of an 6-[.alpha.-(amino)substituted acetamido]penicillanic acid or the corresponding 7-[.alpha.-(amino)substituted acetamido]ceph-3-em-4-carboxylic acid with a reactive nucleofugic derivative of a 3-methyleneaminoimidazolidin-2-on-1-carboxylic acid.

REFERENCES:
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patent: 3972870 (1976-08-01), Konig et al.
patent: 3974140 (1976-08-01), Konig et al.
patent: 3974141 (1976-08-01), Konig et al.
patent: 3974142 (1976-08-01), Konig et al.
patent: 3975375 (1976-08-01), Konig et al.
patent: 3978056 (1976-08-01), Konig et al.
patent: 3980792 (1976-09-01), Konig
patent: 3983105 (1976-09-01), Konig et al.
Chemical Abstracts, vol. 79, abst. no. 18697y, (1973), (Abst. of German Offen. 2,152,968).

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