.beta.-Lactam antibiotics

Details .beta.-Lactam antibiotics .beta.-Lactam antibiotics

1983-04-27

1985-09-10

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602391, 514197, A61K 3143, A61K 31495, C07D49954

Patent

active

045406880

ABSTRACT:
Compounds of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof have antibacterial activity: ##STR1## wherein R is hydrogen, C.sub.1-6 alkylcarbonyl or C.sub.1-6 alkyl; R.sup.1 is hydrogen or hydrocarbon; R.sup.2 is hydrogen, or optionally substituted hydrocarbon or optionally substituted heterocyclyl or CXR.sup.d, where X is O or S and R.sup.d is hydrogen or optionally substituted hydrocarbon or optionally substituted heterocyclyl; or R.sup.1 and R.sup.2 together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl group. A process for the preparation of such compounds and compositions comprising them, are also described.

REFERENCES:
patent: 3487074 (1969-12-01), Sheehan
patent: 4189482 (1980-02-01), Truener et al.
patent: 4229348 (1980-10-01), Oi et al.
patent: 4349551 (1982-09-01), Bentley et al.
patent: 4416883 (1983-11-01), Bentley

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