.beta.-Lactam antibacterial agents

Details .beta.-Lactam antibacterial agents .beta.-Lactam antibacterial agents

1981-01-05

1982-09-21

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

260239A, 2602452T, 424114, 542429, 542443, C07D48704, A61K 3740

Patent

active

043507034

ABSTRACT:
Compounds are described of the formula (II): ##STR1## wherein R.sub.1 is a group such that CO.sub.2 R.sub.1 is an ester group; A.sub.1 is a hydrogen atom; and A.sub.2 is a group CR.sub.2 R.sub.3 R.sub.4 wherein R.sub.2 is a hydrogen atom or a hydroxyl group; R.sub.3 is a hydrogen atom or a lower alkyl group; and R.sub.4 is a hydrogen atom or a lower alkyl group, a benzyl group, a phenyl group or is joined to R.sub.3 to form part of a C.sub.5-7 carboxylic ring or is a group of the formula CH(OH)R.sub.5 or CHX wherein R.sub.5 is a hydrogen atom or lower alkyl group and X is an oxygen atom or a CR.sub.6 R.sub.7 group where R.sub.6 is a hydrogen atom or a lower alkyl, phenyl, CN, CO.sub.2 R.sub.8 where R.sub.8 is a lower alkyl, phenyl or benzyl group and R.sub.7 is a hydrogen atom or a lower alkyl group or is joined to R.sub.6 to form part of a C.sub.5-7 carbocyclic ring. These compounds have been found to possess antibacterial properties. The preparation of these compounds is described.

REFERENCES:
patent: 4206219 (1980-06-01), Christensen et al.
patent: 4223038 (1980-09-01), Smale
patent: 4260627 (1981-04-01), Christensen et al.
patent: 4262009 (1981-04-01), Christensen et al.
patent: 4289696 (1981-09-01), Smale
Bateson et al.; J. Chem. Soc., Chem. Commun., pp. 185-186 (1980).

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