.beta.-Glycerophosphate salts of antimalarial phenanthrenemethan

Details .beta.-Glycerophosphate salts of antimalarial phenanthrenemethan .beta.-Glycerophosphate salts of antimalarial phenanthrenemethan

1983-09-16

1985-03-26

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

260924, A61K 31685, C07C 911

Patent

active

045072884

ABSTRACT:
The compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical containing one to six carbon atoms and R.sub.2 is an alkyl radical containing one to six carbon atoms possess markedly increased activity against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.

REFERENCES:
patent: 4178376 (1979-12-01), Higuchi et al.
patent: 4399283 (1983-08-01), Fisher et al.
Am. J. Trop. Med. Hyg., 31(6), 1982, pp. 1075-1079.
Am. J. Trop. Med. Hyg., 25(6), 1976, pp. 769-774.
J. Med. Chem., 15(7), 1972, pp. 771-775.

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