Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1996-10-28
1998-10-27
Weber, Jon P.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
435822, C12N 910, C12N 120
Patent
active
058277145
ABSTRACT:
A .beta.-galactoside-.alpha.-2,6-sialyltransferase derived from a microorganism belonging to the genus Photobacterium has ben disclosed, having the following physicochemical properties:
(1) action and specificity: transferring sialic acid from cytidine monophosphate-sialic acid to the 6-position of a galactose residue in a sugar chain of a glycoconjugate or in a free sugar chain, or to the 6-position of a monosaccharide having a hydroxyl group on carbon at the 6-position and being capable of forming a glycoconjugate.
(2) optimum pH: 5 to 6;
(3) optimum temperature: 30.degree. C.; and
(4) molecular weight: 64,000.+-.5,000 (determined by gel filtration).
REFERENCES:
Derwent WPI, JP 8154673, English Abstract (Jun. 18, 1996).
Derwent WPI, JP 8173182, English Abstract (Jul. 9, 1996).
Paulson et al, The Journal of Biological Chemistry, vol. 252, No. 7, pp. 2356-2362 (1977).
Weinstein et al, The Journal of Biological Chemistry, vol. 257, No. 22, pp. 13835-13844 (1982).
Miyagi et al, Eur. J. Biochem., vol. 126, pp. 253-261 (1982).
Gross et al, Biochemistry, vol. 28, pp. 7386-7392 (1989).
Bauvois et al, Eur. J. Biochem., vol. 121, pp. 567-572 (1982).
Bendiak et al, Eur. J. Biochem., vol. 128, pp. 355-362 (1982).
Gross et al, Eur. J. Biochem., vol. 168, pp. 595-602 (1987).
Yamamoto et al. (Jul., 1996) J. Biochem., 120(1), "Purification and Characterization of a Marine Bacterial .beta.-Galactoside .alpha.-2, 6-Sialytransferase from Photobacterium damsela JT0160", pp. 104-110.
Fleischer et al. (1993) Biochemistry, 32(8), "Target Sizes of Galactosyltransferase, Sialytransferase, and Uridine Diphosphatase in Golgi Apparatus of Rat Liver", pp. 2076-2081.
Kodama Hisashi
Nakashizuka Motoko
Terada Ichiro
Yamamoto Takeshi
Japan Tobacco Inc.
Weber Jon P.
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