.beta.-(Fluoromethylene)-5-hydroxytryptophan and derivatives and

Details .beta.-(Fluoromethylene)-5-hydroxytryptophan and derivatives and .beta.-(Fluoromethylene)-5-hydroxytryptophan and derivatives and

1987-05-21

1989-04-18

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548496, A61K 31405, C07D20920

Patent

active

048228125

ABSTRACT:
This invention relates to pharmacologically-active novel compounds comprising .beta.-fluoromethylene-5-hydroxytryptophan and derivatives, to methods of inhibiting monoamine oxidase and to treating depression, and to pharmaceutical compositions containing the compounds.

REFERENCES:
patent: 4029807 (1977-07-01), Roldau et al.
patent: 4421767 (1983-12-01), Palfreyman
patent: 4454158 (1984-06-01), Beg
Bioorg. Chem. 14, 103 (1986) Ian A. McDonald et al.

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