.beta.-D-Arabinofuranosylimidazo(4,5-c)pyridine compounds and me

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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424 24, 424 26, 424 27, 424 28, A61K 3170, C07H 1906, C07H 1908, C07H 1910

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043150004

ABSTRACT:
Hydroxy, amino and sulfhydryl derivatives of 1-.beta.-D-arabinofuranosyl-1H-imidazo[4,5-c]pyridine, their corresponding esters and non-toxic pharmaceutically acceptable salts are produced by arabinofuranosylation of the requisite heterocycles with 2,3,5-tri-O-benzyl-.alpha.-D-arabinofuranosyl halide and further reaction to obtain the desired compounds. These water soluble compounds are resistant to adenosine deaminase and exhibit antiviral activity.

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Poonian et al., J. Med. Chem., 22, 958 (1979).
Cook et al., J. Am. Chem. Soc., 98, 1492 (1976).
Glandeman et al., J. Org. Chem., 28, 3004 (1963).

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