Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-04-09
2010-06-01
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S232800, C544S080000, C544S120000, C544S121000, C544S122000, C544S124000, C544S126000
Reexamination Certificate
active
07727985
ABSTRACT:
This invention provides beta-carboline compounds of formula I:wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2and R3are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
REFERENCES:
patent: 6627637 (2003-09-01), Ritzeler et al.
patent: 2004/0110759 (2004-06-01), Ritzeler et al.
patent: 2006/0166987 (2006-07-01), Benesh et al.
patent: 19951360 (2001-05-01), None
patent: WO 00/09492 (2000-02-01), None
patent: WO 01/68648 (2001-09-01), None
patent: WO 03/024936 (2003-03-01), None
patent: WO 03/039545 (2003-05-01), None
patent: WO 2004/092167 (2004-10-01), None
Registr No. 2003:485903, Castro et al. Bioorganic & Medicinal Chemistry Letters 13(2003) (abstract only).
U.S. Appl. No. 11/390,287.
Castro, Alfredo C. et al., “Novel IKK Inhibitors: β-Carbolines,”Bioorganic&Medicinal Chemistry Letters, vol. 13, No. 14 (2003), pp. 2419-2422.
Hottelet, M. et al., “Development of IκB Kinase Inhibitors as Anti-Inflammatory Therapeutics,”Inflammation Research,Birkhaeuser Verlag, vol. 49, No. Supplement 2 (Sep. 24, 2000), p. S91 (Abstract).
Lee, Michael et al., “Down-Regulation of Protein Kinase C in Murine Splenocytes: A Potential Mechanism for 2-Acetylaminofluorene-Mediated Immunosuppression,”Cancer Letters, vol. 101, No. 1 (1996), pp. 53-57.
Palanki, Moorthy S.S., “Inhibitors of AP-1 and NF-κB Mediated Transcriptional Activation Therapeutic Potential in Autoimmune Diseases and Structural Diversity,”Current Medicinal Chemistry, vol. 9, No. 2 (Jan. 2002), pp. 219-227.
Castro Alfredo
Fleming Paul E.
Hepperle Michael E.
Little Jeremy D.
Liu Julie Fields
Bianchi Kristin
Millennium Pharmaceuticals Inc.
Millennium Pharmaceuticals Inc.
Saeed Kamal A
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