Beta-carboline thromboxane synthase inhibitors

Details Beta-carboline thromboxane synthase inhibitors Beta-carboline thromboxane synthase inhibitors

1995-05-05

1997-02-18

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 85, 546 86, 546 87, C07D47104, A61K 3144

Patent

active

056042361

ABSTRACT:
Selected acid functional beta-carboline type derivatives effective as thromboxane synthase inhibitors having the formula: ##STR1## where R.sub.1 and R.sub.2 are monovalent radicals, --(L.sub.a)-- is a linking group of 4 to 8 chain atoms, and A is an acidic group.

REFERENCES:
patent: 2850501 (1958-09-01), Voegtli
patent: 3015660 (1962-01-01), Robinson
patent: 4855295 (1989-08-01), Biere et al.
patent: 5066649 (1991-11-01), Hamminga et al.
Chemical Abstracts, vol. 107, No. 1, 6 Jul. 1987, Columbus, Ohio, US; abstract no. 4667y.
Chemical Abstracts, vol. 197, No. 13, 27 Sep. 1982, Columbus, Ohio, US; abstract no. 110249y.
Chemical Abstracts, vol. 55, No. 19, 18 Sep. 1961, Columbus, Ohio, US; abstract no. 18788e.
Chemical Abstracts, vol. 58, No. 5, 4 Mar. 1963, Columbus, Ohio, US; abstract no. 4499e.

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