Beta-carboline derived guanidine alkaloids, tiruchenduramine

Details Beta-carboline derived guanidine alkaloids, tiruchenduramine Beta-carboline derived guanidine alkaloids, tiruchenduramine

2004-03-30

2009-12-01

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S292000

Reexamination Certificate

active

07626025

ABSTRACT:
A novel β-carboline guanidine derivative tiruchenduramine (1)and its derivatives are disclosed. These compounds have been isolated from the Indian ascidianSynoicum macroglossum. These compounds are useful in the treatment of diabetic disorder by providing inhibition of α (alpha)glucosidase.

REFERENCES:
patent: WO 03/033496 (2003-04-01), None
patent: WO 03/065036 (2003-08-01), None
Davidson, Bradley S., “Ascidians: Producers of Amino Acid Derived Metabolites”, Chem. Rev., 1993, vol. 93, No. 5, pp. 1771-1791.
Ortega, Maria J., et al., “New Rubrolides from the Ascidian Synoicum blochmanni”, Tetrahedron, vol. 56, No. 24, Jun. 2000, pp. 3963-3967.
Reddy, M. Venkata Rami, et al., “New Lamellarin Alkaloids from an Unidentified Ascidian from the Arabian Sea”, Tetrahedron, vol. 53, No. 10, Mar. 10, 1997, pp. 3457-3466.

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