Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-12-11
1980-05-20
Morgenstern, Norman
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602391, 2602452R, A61K 3143, C07D49944
Patent
active
042039924
ABSTRACT:
(2S,5R,6S)-6.beta.-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hepta ne-2-carboxylic acid, S,S-dioxide, physiologically acceptable salts thereof and readily hydrolyzable ester thereof inhibit the action of the .beta.-lactamase enzyme RTEM.
REFERENCES:
patent: 3197466 (1965-07-01), Chow et al.
patent: 3741959 (1973-06-01), Looker et al.
Fisher et al., Annual Reports in Med. Chem. 13, 239 (1978).
Cole, Enzyme Biotechnology, p. 222 (1978).
Clayton, J. Chem. Soc. (c) 2123 (1969).
Loosemore et al., J. Org. Chem. 43 (18) 3611 (1978).
Pratt et al., Proc. Nat'l Acad. Sci. USA, 75 (9), 4145 (1978).
English et al., Antimicrobial Agents & Chemotherapy 14 (3) 414 1978.
Sykes et al., J. of Antimic Chemotherapy 2, 115 (1976).
Gordon Eric M.
Koster William H.
Barrack Donald J.
Clarke Vera C.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Lovercheck Dale
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