Organic compounds -- part of the class 532-570 series – Organic compounds – Boron acids or salts thereof
Patent
1992-08-14
1995-08-15
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Boron acids or salts thereof
549213, 560 29, C07F 502
Patent
active
054421004
ABSTRACT:
A compound having the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen or C.sub.1-C.sub.4 alkyl; n is 2-4; X is aryl, substituted aryl or C.sub.1-C.sub.6 alkyl; Y is selected from the group consisting of hydrogen, amino acid, dipeptide or tripeptide linked through the C-terminal carboxylic acid, and amine protecting group is presented.
REFERENCES:
patent: 2872479 (1959-02-01), Letsinger et al.
patent: 3912595 (1975-10-01), Philipp et al.
patent: 4532064 (1985-07-01), Boskamp
patent: 4537707 (1985-08-01), Severson, Jr.
patent: 4566985 (1986-01-01), Bruno et al.
patent: 4652394 (1987-03-01), Inamorato
patent: 4704233 (1987-11-01), Hartman et al.
patent: 4747977 (1988-05-01), Whitehead et al.
patent: 4842758 (1989-06-01), Crutzen
patent: 4842769 (1989-06-01), Shulman et al.
patent: 4900475 (1990-02-01), Ramachandran et al.
patent: 4908150 (1990-03-01), Hessel et al.
patent: 4963655 (1990-10-01), Kinder et al.
patent: 5039446 (1991-08-01), Estell
patent: 5169841 (1992-12-01), Kleeman et al.
CA63: 11597g Apr. 1965.
CA110: 192887d Nov. 1989.
"Inhibition of Subtilisin by Substituted Arylboronic Acids", M. Phillip and S. Marupuri, FEBS Letters, vol. 133, No. 1, pp. 36-38 (1981).
"Kinetics of Subtilisin and Thiolsubtilisin", M. Philipp and M. Bender, Molecular and Cellular Biochemistry 51, pp. 5-32 (1983).
"Protein Structure and Function", L. Stryer, Biochemistry, Third Edition, pp. 15-21 (1988).
"New Preparation of Aminoboronic Acids", A. Dicko, M. Montury and M. Baboulene, Synthetic Communications, pp. 459-463 (1988).
"Synthesis of Functionality Substituted Alkylboronic Acids", D. N. Butler and A. H. Soloway, Journal of the American Chemical Society, pp. 484-487 (1966).
"Catecholborane: A New Hydroboration Reagent", C. F. Lane and G. W. Kabalka, Tetrahedron, vol. 32, pp. 981-990 (1976).
"Prepartion and Use of Organoboranes in Organic Synthesis", F. R. Hartley, The Chemistry of the Metal-Carbon Bond, vol. 4, pp. 308-410 (1987).
"Boronic Esters in Stereodirected Synthesis", D. S. Matteson, Tetrahedron vol. 45, No. 7, pp. 1859-1885 (1989).
"The Reducing Action of Some Organoboronic Acids," J. R. Johnson, M. G. Van Campen, Jr., and O. Grummitt, Organoboron Compounds, pp. 111-115 (1938).
"Protection for the Amino Group," T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 2d Edition, pp. 309-405 (1989).
"Electrophilic Displacement Reactions", H. G. Kuivila, J. F. Reuwer, Jr. and J. A. Mangravite, Canadian Journal of Chemistry, vol. 41, pp. 3082-3090 (1963).
"A Polarimetric and .sup.11 B and .sup.13 C Nuclear Magnetic Resonance Study of the Reaction of the Tetrahydroxyborate Ion with Polyols and Carbohydrates," J. G. Dawber et al, Journal of Chemical Society, vol. 1, pp. 41-56 (1988).
"Kinetics of Subtilisin and Thiolsubtilisin", M. Philipp and M. L. Bender, Molecular & Cellular Biochemistry, vol. 51, pp. 5-32 (1983).
"Equilibria Between Borate Ion and Some Polyols in Aqueous Solution", J. M. Conner and V. C. Bulgrin, J. Inorg. Nucl. Chem., vol. 29, pp. 1953-1961 (1967).
"Studies on Borate Esters I", M. Van Duin, J. A. Peters, A. P. Kieboom, and H. Van Bekku, Tetrahedron, vol. 40, No. 15, pp. 2901-2911 (1984).
"Raman Study of Aqueous Monoborate-Polyol Complexes. Equilibria in the Monoborate-1,2-Ethanediol System", R. P. Oertel, Inorganic Chemistry, vol. 11, No. 3, pp. 554-549 (1972).
"Mechanism of the Complexation of Boron Acids with Catechol and Substituted Catechols", R. Pizer and L. Babcock, Inorganic Chemistry, vol. 16, No. 7, pp. 1677-1681 (1977).
"N-Trimethylsilylenamine durch Silylierung von deprotonierten Iminen", H. Ahlbrecht and D. Liesching, Communications, pp. 746-748 (1976).
"N,N-Bis[trimethylsilyl]-enamine durch Silylierung von N-Trimethylsilyliminen oder Hexahydro-1,3,5-triazinen mit Trimethylsilyl-triflat", H. Ahlbrecht and E. Duber, Communications, pp. 273-275 (Apr. 1982).
Pending U.S. Application Ser. NO. 693,515, Panandiker et al, filed Apr. 30, 1991.
Pending U.S. Application Ser. No. 748,153, Panandiker, filed Aug. 21, 1991.
Bjorkquist David W.
Panandiker Rajan K.
Allen George W.
Burn B. M.
Raymond Richard L.
The Procter & Gamble & Company
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