.beta.-Alkoxyacrylates against malaria

Details .beta.-Alkoxyacrylates against malaria .beta.-Alkoxyacrylates against malaria

1998-06-22

2000-07-04

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

544183, 546173, 546342, 548187, 548572, 549 58, 549 79, 549499, 560125, 560127, 562507, 562510, C07C25550, C07C22934, C07D25308, C07D33372

Patent

active

060841206

ABSTRACT:
The present invention relates to compounds having the formulae ##STR1## wherein R, R.sup.1, R.sup.6, R.sup.7, Rn.sup.8, X, and Z are defined herein, which are useful in the treatment or prophylaxis of malaria. The compounds of the present invention are especially useful in the treatment or prophylaxis of chloroquine-sensitive and chloroquine-resistant malaria.

REFERENCES:
patent: 4723034 (1988-02-01), Schirmer et al.
patent: 5118710 (1992-06-01), Wingert et al.
patent: 5334607 (1994-08-01), Sauter et al.
patent: 5356931 (1994-10-01), Kirstgen et al.
patent: 5376677 (1994-12-01), Trah
patent: 5389619 (1995-02-01), Doetzer et al.
patent: 5409954 (1995-04-01), Kirstgen et al.
patent: 5563168 (1996-10-01), Brand et al.
Derwent Abstract: FR 2670781A.
Derwent Abstract: WO 9007493A.
Derwent Abstract: EP 460575A.

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