.beta.-Adrenergic blocking agents in the 1,2,3-thiadiazole serie

Details .beta.-Adrenergic blocking agents in the 1,2,3-thiadiazole serie .beta.-Adrenergic blocking agents in the 1,2,3-thiadiazole serie

1974-09-16

1976-02-24

Gallagher, Richard J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260468E, 424270, C07D28506

Patent

active

039404072

ABSTRACT:
Novel 4-[2,3 or 4(3-amino-2-hydroxypropoxy) phenyl]- and 5-[2,3 or 4(3-amino-2-hydroxypropoxy) phenyl]-1,2,3-thiadiazole derivatives which may be further substituted at the C-5 or C-4 position of the thiadiazole ring, respectively, by a lower alkyl, phenyl, trifluoromethyl, carboxy, alkoxycarbonyl, cyano or an aminocarbonyl group, and the pharmaceutically acceptable acid addition salts thereof and processes for the production of such compounds; 4-[4(3-t-butylamino-2-hydroxypropoxy)phenyl]-1,2,3-thiadiazole and 5-[4(3-t-butylamino-2-hydroxypropoxy)phenyl]-1,2,3-thiadiazole are representative of the class. These compounds possess cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals.

REFERENCES:
patent: 3729469 (1973-04-01), Wasson

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