Beta-adrenergic blockade reversal of catabolism after severe...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C424S810000, C530S350000

Reexamination Certificate

active

07098248

ABSTRACT:
Provided herein is a method of method of treating an individual having a severe burn, comprising the step of administering to said individual a pharmacologically effective dose of a beta-adrenergic antagonist.

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patent: 6194578 (2001-02-01), Griffith et al.
patent: 2001/0056068 (2001-12-01), Chwalisz et al.
patent: WO 9604233 (1996-02-01), None
Herndon et al, Lipolysis in burned patients . . . , Archives of Surgery, 1994, Vol. 129/12, pp. 13012-1305.
Hart et al, Anticatabolism agter sever burn . . . , Database Caplus, AN 2001:119741, Abstract, Surg. Forum(2000), vol. 51, pp. 196-197.
Baron et al., “Prolonged use of propranolol safety decreases cardiac work in burned children,”J. Burn Care Rehabil., 18:223-227, 1997.
Breitenstein et al., “Effects of beta-blockade on energy metabolism following burns,”Burns, 16:259-264, 1990.
Chance et al., “Clenbuterol decreases catabolism and increases hypermetabolism in burned rats,”Journal of Trauma,31(3):365-379, 1991.
Hart et al., “Anticatabolism after sever burn: synergism between growth hormone and propranolol,”Abstract inSurg. Forum, 51:196-197, 2000.
Herndon et al., “Effect of propranolol administration on hermodynamic and metabolic responses of burned pediatric patients,”Ann. Surg.208:484-492, 1988.
Herndon et al., “Lipolysis in burned patients is stimulated by the β2receptor for catecholamines,”Arch. Surg., 129:1301-1305, 1994.
Maggi et al., “Beta-1 blockade decreases cardiac work without affecting protein breakdown or lipolysis in severely burned patients,” Surgical Forum, 44(0):25-27, 1993.
Mangano et al., “Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research group,” N. Engl. J. Med., 335:1713-1720, 1996.
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