Bestatin

Details Bestatin Bestatin

1977-06-24

1980-02-19

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562426, 562444, 562503, 562508, 562556, 562564, 424319, 560 20, 560 22, 560 39, C07C 7946, A01N 920

Patent

active

041896041

ABSTRACT:
Bestatin, which is [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, and related compounds which inhibit aminopeptidase B, leucino aminopeptidase and Bleomycin hydrolase, enhance the anti-tumor effect of Bleomycin and exhibit an antifertility effect were synthesized and tested.

REFERENCES:
patent: 2918466 (1959-12-01), Kreysa
patent: 3882161 (1975-05-01), Eichenberger et al.
patent: 4052449 (1977-10-01), Umezawa et al.

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