Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-29
2011-03-29
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S048000
Reexamination Certificate
active
07915276
ABSTRACT:
The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having activity against chitin synthase, which participates in the synthesis of chitin and is essential in the growth of fungi, and having a potent antifungal activity against human pathogenic fungi.
REFERENCES:
patent: 6030978 (2000-02-01), Kim et al.
patent: WO 00/37468 (2000-06-01), None
patent: WO 03/051875 (2003-06-01), None
Mizuta, Hiroyuki et al.: “Smiles Rearrangement in Isoquinolinium Salts”,Chem. Pharm. Bull, vol. 35 (1987) pp. 2238-2242.
Park, Ki Duk et al.: << Synthesis of 13-(substituted benzy) berberine and berberrubine derivaties as antifungal agents >>,Bioorganic&Medicinal Chemistry Letters, 16 (2006), pp. 3913-3916.
Kang Tae Hoon
Kim Sung Uk
Kim Young Kook
Moon Jae Sun
Park Ki Duk
Aulakh Charanjit S
Frommer & Lawrence & Haug LLP
Korea Research Institute of Bioscience and Biotechnology
Santucci Ronald R.
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