Berban derivatives as .alpha..sub.2 -adrenergic antagonists

Details Berban derivatives as .alpha..sub.2 -adrenergic antagonists Berban derivatives as .alpha..sub.2 -adrenergic antagonists

1986-05-23

1989-07-25

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514284, 546 48, 546 71, A61K 3147, C07D45503

Patent

active

048514160

ABSTRACT:
The invention relates to novel racemic or optically active berban derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon atoms or R.sup.1 and R.sup.2 together represent a C.sub.1-3 alkylenedioxy group;

REFERENCES:
Burger, Med. Chem. 2nd ed., pp. 42, 43 (1960).
Szabo et al, Chem. Ber., vol. 4, 109, pp. 1724-1736 (1976).
Toth et al, Jour. Med. Chem., vol. 27, 1411 (1984).
Szabo et al., Chem. Abstracts, vol. 78 (1973), entry 4387q.
Szabo et al, Chem. Abstracts, vol. 78 (1973), entry 4388r.
L. Szabo et al, Chem. Ber., vol. 109, pp. 3390-3403 (1976).
Vizi et al, Journal of Pharmacology & Experimental Therapeutics, vol. 238, pp. 701-706 (1986).
Berbanes: A New Class of Selective .alpha..sub.2 -Adrenoceptor Antagonists, J. Med. Chem. 1987, 30, 1355-1359. E. Sylvester, Vizi et al, 1987 American Chemical Society.
Chem. Ber. 105, pp. 3231-3243 (1972).dbd.Chem. Abstracts (R); Chem. Ber. 105, pp. 3215-3230 (1972).dbd.Chem. Abstracts (S): Chem. Ber 109, pp. 1724-1736 (1976); J. Med. Chem. 27, pp. 1411-1415 (1984); Acta Chim. Acad. Sci., pp. 313-314 (1982), and Drugs of the Future, 10 (10), pp. 841-857 (1985).

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