Benzylthiazolone inhibitors of estrogen-related receptors (ERR)

Details Benzylthiazolone inhibitors of estrogen-related receptors (ERR) Benzylthiazolone inhibitors of estrogen-related receptors (ERR)

2011-07-12

2011-07-12

Chu, Yong (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S369000, C514S370000, C514S236800, C514S254020, C514S227800, C544S133000, C544S369000, C544S058700

Reexamination Certificate

active

07977489

ABSTRACT:
Compounds of the following general structure for use in compositions and methods for modulating the activity of nuclear receptors are provided:The compounds are useable in compositions and methods for modulating the estrogen related receptors and are agonists, partial agonists, antagonists. or inverse agonists of ERR or ERRα.

REFERENCES:
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Vippagunta et al, “Crystalline Solids”, Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
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Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
Busch et al., “Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha”, Journal of Medicinal Chemistry, 2004, 47(23), 5593-5596.

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