Benzyloxy or alkoxy substituted phenylaminobenzamides

Details Benzyloxy or alkoxy substituted phenylaminobenzamides Benzyloxy or alkoxy substituted phenylaminobenzamides

1985-01-09

1985-10-22

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546226, 548539, 564163, C07C10328, C07D29518

Patent

active

045490163

ABSTRACT:
Novel 2-(hydroxyphenylamino)benzamides and oxidation products thereof, useful as inhibitors of lipoxygenase, are of the formulas ##STR1## wherein R is hydrogen, lower-alkyl, halo or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and N.dbd.Z is amino or substituted amino. The compounds of Formula I are prepared by de-etherification of the corresponding alkyl or benzyl ethers; and the compounds of Formula II are prepared by oxidation of the compounds of Formula I where R' is hydrogen and OH is in the 4-position.

REFERENCES:
Juby et al., J. Med. Chem. 11, 111-117, (1968).
Cain et al., J. Med. Chem. 18, 1110-1117, (1975).
Iwao et al., J. Am. Chem. Soc. 104, 5531-5533, (1982).
Chatterjee et al., J. Indian Chem. Soc. 46, 103-108, (1969).
Chen et al., J. Med. Chem. 21, 868-874, (1978).

Affiliated with

Also associated with

Rating

Benzyloxy or alkoxy substituted phenylaminobenzamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzyloxy or alkoxy substituted phenylaminobenzamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzyloxy or alkoxy substituted phenylaminobenzamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-123024