Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-07-25
2006-07-25
Maier, Leigh C. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S025000, C514S042000, C514S053000
Reexamination Certificate
active
07081448
ABSTRACT:
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structurewhereinR1, R2, R3, R4, R5, R6, R7, and R8are each, independently, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, benzoyl, or —SO3H;R9is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, or alkoxy of 1–6 carbon atoms;R10is hydrogen, —NO2, —NHR11, —NHR13, —N(R13)2, —NCH3R13, —NHCO2alkyl, wherein the alkyl moiety contains 1–6 carbon atoms, alkylsulfonamide of 1 to 4 carbon atoms,Z is O or S;R11is an α-amino acid in which the α carboxyl group forms an amide with the nitrogen of R10, wherein if said amino acid is glutamic acid or aspartic acid, the non-α carboxylic acid is an alkyl ester in which the alkyl moiety contains from 1–6 carbon atoms;R12is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, alkoxy of 1–6 carbon atoms, acyl of 2–7 carbon atoms, or benzoyl;R13is hydrogen, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, or benzoyl;or a pharmaceutically acceptable salt thereof.
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Fish & Richardson P.C.
Maier Leigh C.
Wyeth
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