Benzylketone phospholipase A.sub.2 inhibitors

Details Benzylketone phospholipase A.sub.2 inhibitors Benzylketone phospholipase A.sub.2 inhibitors

1990-06-01

1991-12-24

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514678, 514679, 514680, 568 27, 568 31, 568 42, 568 43, A61K 31135

Patent

active

050753398

ABSTRACT:
The invention relates to benzylketone phospholipase A.sub.2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A.sub.2 -mediated conditions in mammals by administration of a therapeutically effective amount of such a benzylketone phospholipase A.sub.2 inhibitor. These compounds are also intermediates in the synthesis of other PLA.sub.2 inhibitors.

REFERENCES:
patent: 3979444 (1976-09-01), Lednicer et al.
patent: 4239780 (1980-12-01), Wallach
D. P. Wallach and V. J. Brown, Biochemical Pharmacology 30 1315 (1981).

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