Benzylidene-lactone derivatives of fenamates and their thiocarbo

Details Benzylidene-lactone derivatives of fenamates and their thiocarbo Benzylidene-lactone derivatives of fenamates and their thiocarbo

1995-05-24

1997-12-30

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549293, 549416, C07D30930, A61K 3135

Patent

active

057031193

ABSTRACT:
The manufacture and use of compounds of the formula ##STR1## wherein Y is O or S, R.sub.1 is hydrogen or alkyl, and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or various substituent groups, and pharmaceutically acceptable acid addition salts thereof. The compounds have activity as inhibitors of the IL-I or other agonist-induced proteoglycan degradation in bovine nasal cartilage and pharmaceutical compositions containing such compounds are described to treat conditions advantageously affected by such inhibition including arthritis.

REFERENCES:
patent: 4431656 (1984-02-01), Katsumi et al.
patent: 5217709 (1993-06-01), Lagrange et al.

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