Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-26
1994-10-25
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549475, 549416, 549295, 514459, 514424, 514327, 548543, 546216, A61K 3134, C07D30788
Patent
active
053589645
ABSTRACT:
The manufacture and use of compounds of the formula ##STR1## wherein Y is O or S, R.sub.1 is hydrogen or alkyl, and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or various substituent groups, and pharmaceutically acceptable acid addition salts thereof. The compounds have activity as inhibitors of the IL-I or other agonist-induced proteoglycan degradation in bovine nasal cartilage and pharmaceutical compositions containing such compounds are described to treat conditions advantageously affected by such inhibition including arthritis.
REFERENCES:
patent: 4431656 (1984-02-01), Katsumi et al.
patent: 5217709 (1993-06-01), Lagiange et al.
Baragi Vijaykumar
Boschelli Diane H.
Connor David T.
Renkiewicz Richard R.
Ashbrook Charles W.
Daignault Ronald A.
Fan Jane T.
Warner-Lambert & Company
LandOfFree
Benzylidene-lactone and their thiocarbonyl analogs as inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzylidene-lactone and their thiocarbonyl analogs as inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzylidene-lactone and their thiocarbonyl analogs as inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-135693