Benzylidene derivatives

Details Benzylidene derivatives Benzylidene derivatives

1981-08-03

1983-08-23

Reamer, James H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424309, 424324, 560 35, 562440, 564171, 564174, C07C10130, A61K 31195

Patent

active

044003943

ABSTRACT:
Compounds of the formula: ##STR1## in which X.sub.1, X.sub.2 and X.sub.3, which are identical or different, each represent hydrogen, halogen, methyl, or methoxy, n represents an integer from 1 to 10, and R represents hydroxyl, OM, NH.sub.2, NH(CH.sub.2).sub.3 --COOH, --NH(CH.sub.2).sub.3 --COOM, (where M represents an alkali metal atom), NH(CH.sub.2).sub.3 --COOC.sub.2 H.sub.5, NH-cycloalkyl, NH-phenyl, NH-benzyl (where the benzyl radical is unsubstituted or substituted by halogen or trifluoromethyl), NH-alkyl, N(alkyl).sub.2 and N-(alkyl)-(benzyl), the aforesaid alkyls being straight or branched and having from 1 to 4 carbon atoms and the aforesaid cycloalkyls having from 3 to 6 carbon atoms, except that when X.sub.1 and X.sub.3 are both hydrogen, n is 1 and R is OH, X.sub.2 is not chlorine in the 5-position are useful in the treatment of epilepsy by oral or parenteral administration.

REFERENCES:
patent: 3966793 (1976-06-01), Schmitt
patent: 4089875 (1978-05-01), Jaunin
Al-Sayyab et al., J. Chem. Soc(c), pp. 406-410 (1968).
Hope et al., Tet. Letters, #22, pp. 2261-2264 (1972).
Wilson et al., "Org. Medicinal & Pharmaceutical Chem.", J. B. Lippincott Co., pp. 39, 40 & 50 (1954).

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