Benzylidene derivatives

Details Benzylidene derivatives Benzylidene derivatives

1976-07-16

1978-06-13

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260519, 260404, 260559D, 260559A, 260559P, 260591, 260559R, 424309, 424319, 560 35, C07C10329

Patent

active

040949923

ABSTRACT:
Compounds of the formula: ##STR1## in which X.sub.1, X.sub.2 and X.sub.3, which are identical or different each represent hydrogen, halogen, methyl, or methoxy, n represents an integer from 1 to 10, and R represents hydroxyl, OM, NH.sub.2, NH(CH.sub.2).sub.3 --COH, --NH(CH.sub.2).sub.3 --COOM, (where M represents an alkali metal atom), NH(CH.sub.2).sub.3 --COOC.sub.2 H.sub.5, NH-cycloalkyl, NH-phenyl, NH-benzyl (where the benzyl radical is unsubstituted or substituted by halogen or trifluoromethyl), NH-alkyl, N(alkyl).sub.2 and N-(alkyl)-(benzyl), the aforesaid alkyls being straight or branched and having from 1 to 4 carbon atoms and the aforesaid cycloalkyls having from 3 to 6 carbon atoms, except that when X.sub.1 and X.sub.3 are both hydrogen, n is 1 and R is OH, X.sub.2 is not chlorine in the 5-position are useful in the treatment of epilepsy by oral or parenteral administration.

REFERENCES:
patent: 3371085 (1968-02-01), Reeder
patent: 3429874 (1969-02-01), Topliss
Halpern et al., Aust. J. Chem. 1974, vol. 27, pp. 2047-2051.
Al-Sayyab et al., J. Chem. Soc. (c) 1968, pp. 406-410.

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