Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2004-09-29
2010-11-09
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S646000, C514S658000, C585S025000, C585S026000
Reexamination Certificate
active
07829597
ABSTRACT:
The present invention is directed to compounds of formula (I)which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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Golde, T.E. “Alzheimer disease therapy: Can the amyloid cascade be halted?”, J'nal of Clinical Investigation, Jan. 2003, vol. 111, No. 1, pp. 11-16.
Nantermet Philippe G.
Rajapakse Hemaka Anthony
Selnick Harold G.
MacMillan Keith D.
Merck, Sharp & Dohme, Inc.
Todaro John C.
Ward Paul V.
Wilson James O.
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