Benzylamine analgesics

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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424305, 424330, A61K 31135, A61K 3122, A61K 31215

Patent

active

040176371

ABSTRACT:
Reaction of benzalcyclanones with secondary amines affords aminobenzylcyclohexanones, which, upon reduction, yield aminobenzylcyclohexanols having potent analgesic activity. Epimeric aminobenzylcycloalkanols having analgesic activity are prepared by the reaction of C-phenyl nitrones with cycloalkenes to form benzisoxazoles, treatment with alkyl halide to form the corresponding benzisoxazolium halides, followed by hydrogenolysis.

REFERENCES:
patent: 3567765 (1971-03-01), Thiele
patent: 3644641 (1972-02-01), Marshall
patent: 3652589 (1972-03-01), Flick

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