Benzylamine analgesics

Details Benzylamine analgesics Benzylamine analgesics

1977-06-29

1979-05-22

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265C, 26050118, 260562R, 42424857, 424274, 424316, 424330, 544106, 560155, C07C 9114

Patent

active

041559355

ABSTRACT:
Reaction of benzalcyclanones with secondary amines affords aminobenzylcyclohexanones, which, upon reduction, yield aminobenzylcyclohexanols having potent analgesic activity. Epimeric aminobenzylcycloalkanols having analgesic activity are prepared by the reaction of C-phenyl nitrones with cycloalkenes to form benzisoxazoles, treatment with alkyl halide to form the corresponding benzisoxazolium halides, followed by hydrogenolysis.

REFERENCES:
patent: 2767185 (1956-10-01), Baltzly et al.
patent: 3320252 (1967-05-01), Doebel et al.

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