Benzylamidine derivatives with serotonin receptor binding activi

Details Benzylamidine derivatives with serotonin receptor binding activi Benzylamidine derivatives with serotonin receptor binding activi

1997-03-20

1999-10-19

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544242, C07D23906

Patent

active

059691379

ABSTRACT:
This invention relates to compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: ##STR1## wherein R.sup.1 is selected from a group of Formula i and ii: ##STR2## n is 1-3; R.sup.2 is selected from H and C.sub.1-6 alkyl;

REFERENCES:
The Merck Index, 11th edition, 1989, p. 1591.
Brimblecome et al., Br. J. Pharmac., 1969, vol. 37, pp. 425-435.
Boudier et al., Life Sciences, 1975, vol. 17, No. 3, pp. 377-385.
Jen et al., Journal of Medicinal Chemistry, 1975, vol. 18, No. 1, pp. 90-99.
Wentland et al., J. Med. Chem., 1987, vol. 30, pp. 1482-1489.
Schoeffter et al., European Journal of Pharmacology, 1991, vol. 196, pp. 213-216.
Huang et al, "synthesis of 2-(benzoylmethylene), etc" CA 108:21818, (1988).

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