Benzylalcohol derivative and process for preparing

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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424316, 26050118, 549443, 564271, 564304, 564357, 564358, 564363, 564375, 564381, A01N 3730, C07C 9116

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active

044903928

ABSTRACT:
A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, halogen or alkoxy having one to four carbon atoms, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by reducing a compound of the formula: ##STR2## wherein R' is benzyloxy, halogen or alkoxy having one to four carbon atoms, and Ring A is the same as defined above, to give a compound of the formula: ##STR3## wherein R' and Ring A are the same as defined above, and when R' is benzyloxy, if required, further subjecting the compound [I'] to catalytic hydrogenation to give a compound of the formula: ##STR4## wherein Ring A is the same as defined above. The benzylalcohol derivative [I] is useful as an anti-diabetic agent.

REFERENCES:
patent: 3139441 (1964-06-01), Biel
patent: 3250803 (1966-05-01), Dijk
patent: 3253034 (1966-05-01), McLoughlin
patent: 3976695 (1976-08-01), Kaiser et al.
patent: 4011319 (1977-03-01), Kaiser et al.
patent: 4032575 (1977-06-01), Ikezaki et al.
patent: 4052506 (1977-10-01), Kaiser et al.

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