Benzylalcohol amine derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2603437, 26050111, 26050112, 26050118, 26050119, 260592, 424280, 424316, 424330, C07C 9122

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active

040325750

ABSTRACT:
A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.

REFERENCES:
patent: 3255249 (1966-06-01), Howe et al.
patent: 3869474 (1975-03-01), Miura et al.
Klosa, "Journal fur Praktiscke Chemie," vol. 36, pp. 1-4 (1967).
Burger, "Medicinal Chemistry," 2nd Ed., p. 597 (1960).
Thrift, "Jour. Chem. Soc. London," Series C, pp. 288-293 (1967).

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