Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives

Details Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives

2005-12-21

2009-08-18

Shiao, Rei-tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S329000, C546S224000, C546S208000

Reexamination Certificate

active

07576105

ABSTRACT:
The present invention is directed to N-benzyl substituted (piperidin-4-yl)aminobenzamido derivatives which are delta-opioid receptor modulators.

REFERENCES:
patent: 6130222 (2000-10-01), Roberts et al.
patent: 6436959 (2002-08-01), Carson et al.
patent: WO 99/33806 (1999-07-01), None
patent: WO 02/48112 (2002-06-01), None
patent: WO 03/020716 (2003-03-01), None
Thomas, James B. et al., “Factors Influencing Agonist Potency Selectivity Opioid Receptor Are Revealed in Structure-Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl) arylamino]-N,N-diethylbenzamides”, J. Med. Chem., vol. 44, pp. 972-987, 2001.
Podlogar, Brent L. et al., “Synthesis and Evaluation of 4-(N, N-Diarylamino) piperidines with High Selectivity to the -Opioid Receptor: A Combined 3D-QSAR Ligand Docking Study”, Drug Design and Discovery, vol. 17, No3. 1, pp. 34-50, 2000.

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