Benzyl(Idene)-lactam derivatives, their preparation and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S253070, C514S253120, C544S360000, C544S363000

Reexamination Certificate

active

06924289

ABSTRACT:
The present invention relates to lactam derivatives of the formulawherein R1, R2, R3, A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for their preparation, and to their medicinal use as selective agonists and antagonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1Aand 5-HT1Dreceptors. These compounds are useful in treating or preventing migraine, depression and other disorders for which a 5-HT1agonist or antagonist is indicated.

REFERENCES:
patent: 6467084 (2002-10-01), Howard

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