Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators

Details Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators

2011-06-14

2011-06-14

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C562S441000, C558S166000, C549S068000, C549S480000, C548S214000, C548S245000, C548S246000, C548S372500, C548S557000, C548S558000, C514S114000, C514S372000, C514S380000, C514S403000, C514S404000, C514S426000, C514S447000, C514S472000, C514S561000, C514S646000

Reexamination Certificate

active

07960588

ABSTRACT:
Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.

REFERENCES:
Database CAPLUS on STN, Acc. No. 1982:68469, Vejdelek et al., Collection of Czechoslovak Chemical Communications (1981), 46(9), p. 2234-2244 (abstract).

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