Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1983-04-18
1985-01-29
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
260396N, 564433, 514826, A01N 3302, A61K 31335, C07C 5010, C07C 9710
Patent
active
044965907
ABSTRACT:
Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Y is C.sub.n H.sub.2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein --Y--OH is replaced by --COCH.sub.3.
REFERENCES:
patent: 3513199 (1970-05-01), Ross et al.
patent: 3792090 (1974-02-01), Kalopissis et al.
patent: 3884625 (1975-05-01), Kalopissis et al.
patent: 3895063 (1975-07-01), Sallman et al.
Patai, The Chemistry of the Hydroxyl Group, part 2, 1971, pp. 1004, 1006.
I. Molnar and Th. Wagner-Jauregg, Helv. Chim. Acta 52, 401-408, (1969).
Bell Malcolm R.
Schlegel Donald C.
Covington Raymond
DuPont Paul E.
Hollrah Glennon H.
Johnson Thomas L.
Sterling Drug Inc.
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