Benzoylthio compounds, their preparation and their use as drugs

Details Benzoylthio compounds, their preparation and their use as drugs Benzoylthio compounds, their preparation and their use as drugs

1983-11-21

1985-02-19

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, 260455R, 514 19, C07C15300, C07C10352, C01B 2510

Patent

active

045004676

ABSTRACT:
Benzoylthio compounds of the formula I ##STR1## where R.sup.1 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.2 and R.sup.4 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.4 -alkylthio, a carboxylic ester group, carboxamido or acylamino or are each an aryl, hetaryl, arylalkylene or hetarylalkylene radical which is unsubstituted or substituted in the aryl moiety by hydroxyl, C.sub.1 -C.sub.4 -alkoxy, arylalkoxy or halogen, R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together may furthermore be a radical --(CH.sub.2).sub.p -- (p=2, 3, 4), --CH.sub.2 --S--CH.sub.2 -- or --CH.sub.2 --C.sub.6 H.sub.4 --CH.sub.2 --(ortho), X is NH or sulfur, m and n are identical or different and are each 0 or 1, and q is 0 or 1 where X is S, and is 0 where X is NH, and their salts with physiologically tolerated bases, their preparation, drugs containing these compounds and the use of these drugs in treating disorders.

REFERENCES:
patent: 4127729 (1978-11-01), Ondetti
patent: 4156785 (1979-05-01), Ondetti et al.
patent: 4339600 (1982-07-01), Ondetti et al.
Chem. Abstr., vol. 92, (1980), 215770.
Derwent, Abstr., J54125-669, 20.3.78.
Organic Chem. of Bivalent Sulfur, vol IV, 1962, pp. 16, 29.

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