Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-09-25
1990-02-27
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544316, C07D23934, A61K 31505
Patent
active
049046683
ABSTRACT:
A benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, or the formula: ##STR2## wherein each of X.sub.1 is X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, characterized in that its average particle size is not larger than 1 .mu.m.
REFERENCES:
Haga et al., Chemical Abstracts, vol. 104, entry 207302m (1986).
Haga et al., Chemical Abstracts, vol. 105, entry 226077d (1986).
Knodo et al., Chemical Abstracts, vol. 108, entry 44042t (1988).
Nishiyama et al., Chemical Abstracts, vol. 106, entry 156284p (1987).
Chemical Abstracts, vol. 91, No. 19, Nov. 5, 1979, Columbus, Ohio, USA, Barltrop, D. et al, "Effect of Particle Size on Lead Absorption from the Gut.", p. 153, Abstract No. 152 327d & Arch. Envior. Heath, 1979, 34(4), 280-5.
Haga Takahiro
Kikuchi Masahiro
Kondo Nobuo
Koyanagi Toru
Nakajima Tsunetaka
Ford John M.
Ishihara Sangyo Kaisha Ltd.
The Green Cross Corporation
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