Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-21
1998-07-21
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514423, 546226, 548539, A61K 31445, A61K 3140, C07D21106, C07D29500
Patent
active
057835870
ABSTRACT:
Benzoyl piperidines and pyrrolidines and compounds of related structure are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating depression, alcoholism and schizophrenia, and for improving memory encoding.
REFERENCES:
patent: 3406177 (1968-10-01), Yoho
patent: 3463855 (1969-08-01), Yoho
Shono et al. Drug Metab. Dispos. (1981), 9(5), 476-80), 1981.
Nilsson Lena
Rogers Gary A.
Kifle Bruck
Shah Mukund J.
The Regents of the University of California
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