Benzoyl piperidines/pyrrolidines for enhancing synaptic response

Details Benzoyl piperidines/pyrrolidines for enhancing synaptic response Benzoyl piperidines/pyrrolidines for enhancing synaptic response

1995-06-02

1997-07-22

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 89, A61K 31535, C07D49804

Patent

active

056504098

ABSTRACT:
Benzoyl piperidines and pyrrolidines and compounds of related structure are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating depression, alcoholism and schizophrenia, and for improving memory encoding.

REFERENCES:
Takacs, J.M. "A Removable . . . " Tetrahedron Letters, vol. 30, (52) pp. 7321-7324 1989.
Takacs, J.M. "The Magnitude . . . " Tetrahedron Letters, vol. 31, (47) pp. 6765-6788 1990.
T. Shono, et al., "Regioselectivity and Reactivity in Microsomal Hydroxylation of a Series of N-Acyl- and N-Sulfonylamines in Rats", Drug Metab. Dispos. (1981 9(5): 476-480.

Affiliated with

Also associated with

Rating

Benzoyl piperidines/pyrrolidines for enhancing synaptic response does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzoyl piperidines/pyrrolidines for enhancing synaptic response, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzoyl piperidines/pyrrolidines for enhancing synaptic response will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1560110