Benzoyl peroxide flocculent materials and methods of their prepa

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai

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5262321, A61K 31605

Patent

active

059983922

ABSTRACT:
Improved compositions of benzoyl peroxide are prepared by at least partially dissolving benzoyl peroxide in diethylene glycol monoethyl ether to prepare a premixture which forms a flocculent composition of benzoyl peroxide when admixed with water or an aqueous medium. The improved benzoyl peroxide compositions have a small particle size compared with those prepared by conventional grinding techniques and the time and potential hazards associated with grinding are avoided. The small particle size of the benzoyl peroxide flocculents result in increased surface area of active ingredient on the skin for a given concentration of benzoyl peroxide. The flocculent compositions are used to prepare compositions for the topical treatment of acne or other dermatological disorders.

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patent: 5276202 (1994-01-01), Ceh et al.
patent: 5460620 (1995-10-01), Smith et al.
patent: 5562642 (1996-10-01), Smith et al.

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