Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1981-10-22
1984-02-21
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 41, 536 179, 536 176, 536 178, A61K 3170, C07H 1520
Patent
active
044329733
ABSTRACT:
The present invention relates to the benzoyl- and .alpha.-hydroxybenzyl-phenyl-oside derivatives of general formula: ##STR1## [in which Z is CO or CHOH, X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5, which are identical or different, each represent an atom of hydrogen, an atom of halogen, an alkyl group with 1 to 4 carbon atoms, an alkyl group with 1 to 4 carbon atoms substituted by one or more atoms of halogen, an OH group, an alkoxy group with 1 to 4 carbon atoms, an alkoxy group with 1 to 4 carbon atoms, substituted by one or more atoms of halogen, a nitro group, a cyano group, a thiocyano group, an isothiocyano group, a NR'R" group (where R' and R", identical or different, each represent an atom of hydrogen or an alkyl group with 1 to 4 carbon atoms) X.sub.1 being able, in addition, to represent an --NH--CS--O--CH.sub.3 group or an --O--C(CH.sub.3).sub.2 CO.sub.2 --R'" group (where R'" is an alkyl group with 1 to 4 carbon atoms and, preferably, an isopropyl group); and R represents a radical ose (the hydroxyl and amine functions of the radical ose being able to be substituted by acyl, alkyl or sulfate groups)], and to their diastereoisomers. It also relates to the method for preparing these derivatives and to their application in therapeutics.
REFERENCES:
patent: 2218569 (1940-10-01), White
patent: 2798079 (1957-07-01), Linn
patent: 3152115 (1964-10-01), Morel et al.
patent: 3356674 (1967-12-01), Ikeda et al.
patent: 3496196 (1970-02-01), Suami et al.
patent: 3960835 (1976-06-01), Robertson
Brown Johnnie R.
Societe de Recherches Industrielles (S.O.R.I.)
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