Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-07-08
1992-10-27
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514375, 514394, 548178, 548179, 548217, 5483097, A61K 3142
Patent
active
051589648
ABSTRACT:
A series of novel N-alkyl N-(alkanesulphonamidoheterocyclicmethyl)-4-alkanesulphonamidophenethylamin es have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. The heterocyclic moiety present in these compounds is a benzo-fused heterocyclic group derived from either benzofuran, benzothiophene, benzoxazole or quinoline, and it is attached to the adjacent methyl group of the molecule by means of the available ring carbon atom which is situated alpha to the hetero atom. These particular compounds are useful in therapy as highly effective anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. Preferred member compounds include N-methyl-N-(5 methanesulphonamidobenzofur-2-ylmethyl)-4-methanesulphonamidophenethylamin e and N-methyl-N-(6 methanesulphonamidoquinol-2-ylmethyl)-4-methanesulphonamidophenethylamine. Methods for preparing all these compounds from known starting materials are provided.
REFERENCES:
patent: 4581457 (1986-04-01), Musser et al.
patent: 4956382 (1990-09-01), Arrowsmith et al.
patent: 4990509 (1991-02-01), Arrowsmith et al.
patent: 5055473 (1991-10-01), Arrowsmith et al.
patent: 5070096 (1991-12-01), Mohrs et al.
Arrowsmith John E.
Cross Peter E.
Thomas Geoffrey N.
Daus Donald G.
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
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