Benzoxazole derivatives and drugs containing the same as the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S575000

Reexamination Certificate

active

07045516

ABSTRACT:
A compound represented by the following general formula (1):wherein R1represents a halogen atom, R2represents hydrogen atom or a lower alkyl group, and R3represents hydrogen atom, a lower alkyl group, a lower alkoxyl group, a hydroxy lower alkyl group, a halogen atom, or a substituted or unsubstituted amino group, wherein a substituent on the amino group is selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkylcarbonyl group, and an amino protective group, or a salt thereof. The compound of the present invention or a salt thereof is useful as an active ingredient of medicaments for preventive and/or therapeutic treatment of conditions of irritable bowel syndrome and digestive tract functional disorder, or condition of diarrhea.

REFERENCES:
patent: 6037342 (2000-03-01), Sato et al.
patent: 2003/0013730 (2003-01-01), Sato et al.
patent: 0 621 271 (1994-10-01), None
patent: 806419 (1997-11-01), None
European Search Report dated Nov. 5, 2001.
International Search Report Jan. 11, 2000.
Sato Yasuo et al., “Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut”, J.Med. Chem., (1998), 41(16), p. 3015-21.

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