Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-04-08
2000-01-18
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548217, 548224, 5462684, C07D41302, C07D26357, A61K 3142
Patent
active
060158271
ABSTRACT:
Benzoxazole carboxamides are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. Representative of the compounds are 2-methyl, 2-t-butyl, 2-phenyl or 2-(4-methoxyphenyl) benzoxazole-4-carboxamide.
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Calvert Alan Hilary
Curtin Nicola Jane
Golding Bernard Thomas
Griffin Roger John
Newell David Richard
Newcastle University Ventures Limited
Shah Mukund J.
Sripada Pavanaram K
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