Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-04
2005-10-04
Berch, Mark (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S105000
Reexamination Certificate
active
06951855
ABSTRACT:
This invention relates to novel compounds of Formula (I) for use as vascular damaging agents:wherein: X is selected from: —O—, —S—, —S(O)—, —S(O2)—, —N(R4)— or —N(R4)CH2C(O)—; R1is independently selected from: amino, halo, hydroxy, —OPO3H2, C1-4alkyl, C1-4alkoxy, N-C1-4alkylamino, N,N-di-C1-4alkanoylamino or C1-4alkylthio wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R2is selected from: hydrogen or C1-4alkyl; R3is selected from: hydrogen or C1-4alkyl; R4is selected from: hydrogen or C1-4alkyl; n is 0, 1 or 2; and p is 0, 1, 2 or 3; or a salt, pro-drug or solvate thereof. The invention also relates to methods for preparing compounds of Formula (I), to their use as medicaments (including methods for the treatment of angiogenesis or disease states associated with angiogenesis) and to pharmaceutical compositions containing compounds of Formula (I).
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Berch Mark
Habte Kahsay
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