Benzoxazinone and benzothiazinone derivatives endowed with cardi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142305, 544 50, 544 92, A61K 3154, A61K 31535, C07D27916, C07D26512

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active

051890348

ABSTRACT:
Benzoxazinone and benzothiazinone derivatives of formula ##STR1## wherein R represents hydrogen, (C.sub.2-6)alkyl, (C.sub.5-7)cycloalkyl, phenyl, substituted phenyl; R.sub.1 and R.sub.2 independently represents hydrogen, halogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy or trifluoromethyl; X is oxygen or sulfur; Y is (C.sub.2-6)alkylene or (C.sub.5-7)cycloalkylene; and salts therewith of pharmaceutically acceptable acids. The compounds possess cardiovascular activity with high specificity for the coronary district.

REFERENCES:
patent: 3459748 (1969-08-01), Krapcho
patent: 3513166 (1970-05-01), Richman
patent: 5071850 (1991-12-01), Rieu
Tashikawa et al. Chemical Abstracts 94:56841 (1981) Abstr. of Heterocycles (1981) 15(1) 427-430.
Robapharm A. G. Chemical Abstracts 60:530e (1963) Abstr. of FR 1,330,365 Jun. 21, 1963.
Krapcho et al., "Synthesis & Pharmaceutical Activity of Compounds . . . (Thiazesin)" Journal of Medicinal Chem. 11(2) (1968) 361-364.
Fessenden et al., "Organic Chemistry" 2nd ed. p. 282 (1982).
Abstract, 1-Pharmacodynamics, vol. 77, (1972), p. 77, No. 745m.
Chemical Abstracts, vol. 79, (1973), No. 73744m & 73745n, p. 40.

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