Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-12-10
1993-02-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142305, 544 50, 544 92, A61K 3154, A61K 31535, C07D27916, C07D26512
Patent
active
051890348
ABSTRACT:
Benzoxazinone and benzothiazinone derivatives of formula ##STR1## wherein R represents hydrogen, (C.sub.2-6)alkyl, (C.sub.5-7)cycloalkyl, phenyl, substituted phenyl; R.sub.1 and R.sub.2 independently represents hydrogen, halogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy or trifluoromethyl; X is oxygen or sulfur; Y is (C.sub.2-6)alkylene or (C.sub.5-7)cycloalkylene; and salts therewith of pharmaceutically acceptable acids. The compounds possess cardiovascular activity with high specificity for the coronary district.
REFERENCES:
patent: 3459748 (1969-08-01), Krapcho
patent: 3513166 (1970-05-01), Richman
patent: 5071850 (1991-12-01), Rieu
Tashikawa et al. Chemical Abstracts 94:56841 (1981) Abstr. of Heterocycles (1981) 15(1) 427-430.
Robapharm A. G. Chemical Abstracts 60:530e (1963) Abstr. of FR 1,330,365 Jun. 21, 1963.
Krapcho et al., "Synthesis & Pharmaceutical Activity of Compounds . . . (Thiazesin)" Journal of Medicinal Chem. 11(2) (1968) 361-364.
Fessenden et al., "Organic Chemistry" 2nd ed. p. 282 (1982).
Abstract, 1-Pharmacodynamics, vol. 77, (1972), p. 77, No. 745m.
Chemical Abstracts, vol. 79, (1973), No. 73744m & 73745n, p. 40.
Alberto Sala
Benedini Francesca
Cereda Roberta
Del Soldato Piero
Grumbling Matthew V.
Italfarmaco S.p.A.
Shah Mukund J.
LandOfFree
Benzoxazinone and benzothiazinone derivatives endowed with cardi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzoxazinone and benzothiazinone derivatives endowed with cardi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzoxazinone and benzothiazinone derivatives endowed with cardi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2205001