Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-04-03
1998-04-07
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514214, 544 89, 540576, C07D26512, A61K 31535
Patent
active
057365431
ABSTRACT:
Compounds based on the benzoxazine ring system ##STR1## are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating schizophrenia, and for improving memory encoding.
REFERENCES:
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Takacs et al. "The magnitude of the Stereodirecting Effect on an Allylic Alkoxy-Substituent in an Amidomercuration Cyclization" (1990) Tetrahedron Letters 31(47): 6765-6768.
Takacs et al. "A Removable Auxiliary for Amidomercuration Reactions: The Stereoselective Preparation of Substituted N-Acyl Pyrrolidines and Piperidines" (1989) Tetrahedron Letters 30(52): 7321-7324.
Lynch Gary S.
Rogers Gary A.
Cortex Pharmaceuticals, Inc.
Ford John M.
The Regents of the University of California
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